Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
According to the definition preceding synthetic dopamine is dopamine that is made or produced outside of the body, making it artificial. Synthetic dopamine is used when there is a lack of dopamine in the brain, it is then added to balance the amount produced and maintained in the brain. This artificial dopamine is added into the cerebral system in attempt to cure the disease
This combination medication is used to treat symptoms of Parkinson's disease or Parkinson-like symptoms (such as shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the brain. Levodopa changes into dopamine in the brain, helping to control movement. Carbidopa prevents the breakdown of levodopa in the bloodstream so more levodopa can enter the brain. Carbidopa can also reduce some of levodopa's side effects such as nausea and vomiting.
Parkinson's Disease Support Group January 2017 Slide!
(For PASSWORDS please contact to our Community Education Staff)
This is a simple methodology of Dopamine. A very important neurotransmitter that regulates our autonomic, voluntary, thinking, mood and sensory functions etc.. It is the base neuro-chemical for human beings.
A Phase 4 - 16306A / NOH402: "RESTORE: A 12-Week clinical study of patients with symptomatic neurogenic orthostatic hypotension to assess sustained effects Of Droxidopa therapy"
Do you or a loved one have..
What does it mean?
A clinical study sponsored by Lundbeck recruiting patients with symptomatic neurogenic orthostatic hypotension to assess sustained effects Of Droxidopa therapy
How long is the study?
The study may involve 12-weeks or more, that is including the double-blind and open-lable treatment The time you will
spend in the study will depend on the number of days you are able to complete
How to participate?
Please take your time to make your decision about taking part. You may discuss your decision with your friends and family. You can also discuss it with your health care team. If you have any questions, you can ask your study doctor for more explanation.
You must be..
18 years or older
Clinical diagnosis of symptomatic orthostatic hypotension associated with Primary Autonomic Failure (PD, MSA or PAF) or NDAN or DBH Deficiency
blood pressure drop of at least 20 mmHg in SBP, within 3 minutes of standing.
But cannot be..
Diagnosis of hypertension that requires treatment with antihypertensive medications
PAny specific uncontrolled cardiac arrhythmia
Diabetic autonomic neuropathy
History of cancer within the past 2 years other than a successfully treated, non-metastatic cutaneous squamous cell or basal cell carcinoma or cervical cancer in situ
Gastrointestinal condition that may affect the absorption of Investigational Medicinal Product (e.g., ulcerative colitis, gastric bypass)