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PARKINSON'S DISEASE


Dopamine in the Brain

This is a simple methology of Dopamine. A very important neurotransmitter that regulates our autonomic, voluntary, thinking, mood and sensory functions etc.. It is the base neuro-chemical for human beings.


Do you or a loved one have..

What does it mean?

This clinical trial is looking to reduce in the number of hours for patients experiencing "OFF" state when taking Tozadenant as an adjunctive therapy with Carbidopa/Levodopa

How long is the study?

    The study may involve 86 weeks, that is including the double-blind and open-lable treatment The time you will spend in the study will depend on the number of days you are able to complete

How to participate?

    Please take your time to make your decision about taking part. You may discuss your decision with your friends and family. You can also discuss it with your health care team. If you have any questions, you can ask your study doctor for more explanation.

You must be..

  • 30-80 of age
  • PD duration of at least 3 years from diagnosis.
  • experiencing end-of-dose “wearing-off” with at least 2.5 hours of OFF
  • be taking at least four doses of a levodopa-containing medication per day, and at least one other concomitant anti-PD medication (dopamine agonists, MAO-B inhibitors, anticholinergic agents, amantadine or entacapone).
  • But cannot be..

  • Known diagnosis of malignant melanoma.
  • Have hypertension with supine systolic BP ≥160
  • taking apomorphine, budipine, istradefylline, tolcapone, or DUOPA™/Duodopa®, within 4 weeks
  • have a moderate to severe hepatic or renal impairment
  • have moderate impulse control disorder
  •  

    if you are interested or someone you know that might be eligible, fill out our survey form here

    What does it mean?

    This clinical trial sponsored by Pfizer is looking to research motor fluctuations due to Parkinson's diesease and evaluate the effects of different doses of the study drug or placebo taken with your Levodopa (L-Dopa)

    How long is the study?

      The study may involve 15-weeks or more, that is including the double-blind and open-lable treatment The time you will spend in the study will depend on the number of days you are able to complete

    How to participate?

      Please take your time to make your decision about taking part. You may discuss your decision with your friends and family. You can also discuss it with your health care team. If you have any questions, you can ask your study doctor for more explanation.

    You must be..

  • 45-85 of age
  • PD duration of at least 3 years from diagnosis.
  • experiencing Total duration of 2.5 hours OFF time each day
  • On a stable dose of L-Dopa of at least 400 mg total daily dose for at least 28 days prior to Day 0 (Randomization)
  • But cannot be..

  • History of surgical intervention for Parkinson’s disease (pallidotomy, thalamotomy, deep brain stimulation, etc.).
  • Psychotic symptoms related to Parkinson’s disease requiring treatment with an antipsychotic medication within 6 months prior to Screening.
  • Currently receiving an antipsychotic, metoclopramide, reserpine, or amphetamine
  • A decrease in systolic blood pressure (BP) of >20 mmHg or in diastolic BP of >10 mmHg or severe Low blood pressure symptoms from standing
  • A positive test for hepatitis B surface antigen or hepatitis C antibody
  •  

    if you are interested or someone you know that might be eligible, fill out our survey form here

    What does it mean?

    A clinical study sponsored by Lundbeck recruiting patients with symptomatic neurogenic orthostatic hypotension to assess sustained effects Of Droxidopa therapy

    How long is the study?

      The study may involve 12-weeks or more, that is including the double-blind and open-lable treatment The time you will spend in the study will depend on the number of days you are able to complete

    How to participate?

      Please take your time to make your decision about taking part. You may discuss your decision with your friends and family. You can also discuss it with your health care team. If you have any questions, you can ask your study doctor for more explanation.

    You must be..

  • 18 years or older
  • Clinical diagnosis of symptomatic orthostatic hypotension associated with Primary Autonomic Failure (PD, MSA or PAF) or NDAN or DBH Deficiency
  • blood pressure drop of at least 20 mmHg in SBP, within 3 minutes of standing.
  • But cannot be..

  • Diagnosis of hypertension that requires treatment with antihypertensive medications
  • PAny specific uncontrolled cardiac arrhythmia
  • Diabetic autonomic neuropathy
  • History of cancer within the past 2 years other than a successfully treated, non-metastatic cutaneous squamous cell or basal cell carcinoma or cervical cancer in situ
  • Gastrointestinal condition that may affect the absorption of Investigational Medicinal Product (e.g., ulcerative colitis, gastric bypass)
  •  

    if you are interested or someone you know that might be eligible, fill out our survey form here