At Neurosearch, our goal is to advance the discovery of cures for neuro-degenerative disorders. This area of our website provides you with the latest information on open clinical research trails for Parkinson's Disease that are currently recruiting at our Ventura and Reseda locations. Please browse the study overviews below. If you feel that you or a loved one may be a candidate for any of the studies, please contact us to learn how we can become a partner in your treatment regimen - and eventually your recovery!
Orthostatic Hypotension Trial
A study of an investigational medication for treatment of Orthostatic Hypotension.
The purpose of this study is to see whether droxidopa is effective in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Disease), Non-diabetic neuropathy, or Beta Hydroxylase deficiency. ..
Systolic blood pressure is transiently and minimally decreased in healthy individuals upon standing. Normal physiologic feedback mechanisms work through neurally-mediated pathways to maintain the standing blood pressure, and thus maintain adequate cerebral perfusion. The compensatory mechanisms that regulate blood pressure upon standing are dysfunctional in subjects with orthostatic hypotension (OH), a condition that may lead to inadequate cerebral perfusion with accompanying symptoms of syncope, dizziness or lightheadedness, unsteadiness and blurred or impaired vision, among other symptoms.
The autonomic nervous system has a central role in the regulation of blood pressure. Primary Autonomic Failure is manifested in a variety of syndromes. Orthostatic hypotension is a usual presenting symptom. Primary Autonomic Failure may be the primary diagnosis, and classifications include pure autonomic failure (PAF), also called idiopathic orthostatic hypotension (Bradbury-Eggleston syndrome) autonomic failure with multiple system atrophy (Shy-Drager syndrome) and also Parkinson's disease. Regardless of the primary condition, autonomic dysfunction underlies orthostatic hypotension.
Orthostatic hypotension may be a severely disabling condition which can seriously interfere with the quality of life of afflicted subjects. Currently available therapeutic options provide some symptomatic relief in a subset of subjects, but are relatively ineffective and are often accompanied by severe side effects that limit their usefulness. Support garments (tight-fitting leotard) may prove useful in some subjects, but is difficult to don without family or nursing assistance, especially for older subjects. Midodrine, fludrocortisone, methylphenidate, ephedrine, indomethacin and dihydroergotamine are among some of the pharmacological interventions that have been used to treat orthostatic hypotension, although only midodrine is specifically approved for this indication. The limitations of these currently available therapeutic options, and the incapacitating nature and often progressive downhill course of disease, point to the need for an improved therapeutic alternative.
The current withdrawal design study will measure the efficacy of droxidopa on symptoms of neurogenic orthostatic hypotension in patients randomized to continued droxidopa treatment versus placebo, following 14 days of double-blind treatment.
droxidopa
droxidopa [also, known as L-threo-3,4-dihydroxyphenylserine, L-threo-DOPS, or L-DOPS] is the International non-proprietary name (INN) for a synthetic amino acid precursor of norepinephrine (NE), which was originally developed by Sumitomo Pharmaceuticals Co., Limited, Japan. It has been approved for use in Japan since 1989. Droxidopa has been shown to improve symptoms of orthostatic hypotension that result from a variety of conditions including Shy Drager syndrome (Multiple System Atrophy), Pure Autonomic Failure, and Parkinson's disease. There are four stereoisomers of DOPS; however, only the L-threo-enantiomer (droxidopa) is biologically active.
The exact mechanism of action of droxidopa in the treatment of symptomatic NOH has not been precisely defined; however, its NE replenishing properties with concomitant recovery of decreased noradrenergic activity are considered to be of major importance.
Droxidopa has been marketed in Japan since 1989. Data from clinical studies and post-marketing surveillance programs conducted in Japan show that the most commonly reported adverse drug reactions with droxidopa are increased blood pressure, nausea, and headache. In clinical studies, the prevalence and severity of droxidopa adverse effects appear to be similar to those reported by the placebo control arm.
If you or the person you care for may be eligible for a study of an investigational medication. Those who qualify will receive all study-related medical care at no cost. Compensation for time and travel may also be provided.
Find out more information and get involved!
Parkinson's Disease Psychosis (PDP) Trial
This study is currently not recruiting, but will start re-enrolling in Spring of 2010. Please feel free to email us if with any questions
Do you or a loved one suffer from Parkinson’s Disease?
In addition to Parkinson's symptoms, are you or the person you care for bothered by any of the following experiences:
- Seeing things that other people cannot see?
- Hearing things that other people cannot hear?
- Believing that you cannot trust others?
- Believing that others are trying to hurt you?
- Other similar thoughts, beliefs, or feelings?
If you or the person you care for may be eligible for a study of an investigational medication. Those who qualify will receive all study-related medical care at no cost. Compensation for time and travel may also be provided.
Find out more information and get involved!
Research Study for Parkinson’s Disease with Dementia
This study is no longer recruiting. Please feel free to email us if you have any questions
Many people are unaware that as Parkinson’s Disease (PD) progresses dementia may also develop over time. Symptoms of Parkinson’s Disease with Dementia may include memory problems, disorientation, confusion, moodiness and lack of motivation.
Physicians are conducting research comparing two approved medications in their ability to relieve symptoms in those with Parkinson’s Disease with Dementia.
Qualified participants will:
- Have had PD for two or more years
- Be between the ages of 50-80
- Have recently experienced any of the above dementia symptoms
- Have a caregiver willing to participate in the study
All study participants will receive active study-related medication and care at no cost. Compensation for travel may also be provided. Insurance is not needed to participate.
Coming Soon - Parkinson's Clinical Research Trial Utilizing Azilect/ Rasagaline!
Find out more information and get involved!